Patch Clamp Amplifiers


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Patch Clamp
More information about this product

HEKA is pleased to introduce the new EPS 16 PROBE SELECTOR. This headstage-multiplexing device is capable of turning an EPC 10 single patch clamp amplifier into a sixteen-channel serial patch clamp device.

Any of HEKA's EPC 10 multi-headstage amplifiers (EPC-10 Double, Triple or Quadro) can also be extended with the EPS 16. In these situations, the result will be a multi-channel patch clamp amplifier capable of combining both parallel and sequential recordings.

The extent of parallel versus sequential extension will depend upon which multi-headstage amplifier the EPS 16 is combined with. For example, if one EPS 16 is used in combination with an EPC 10 Double patch clamp amplifier, the system will be able to record from 2 probes simultaneously (in parallel) and each of these can be multiplexed 8-fold resulting in 16 probes in total.

A system based on the EPC 10 Quadro with one EPS 16 would be able to acquire from 4 probes in parallel with each of these being multiplexed 4-fold; again resulting in a total of 16 probes.

Patch clamp systems with up to 128 channels can be set-up using several PROBE SELECTORs in combination with given sets of EPC 10 Double, Triple or Quadro patch clamp amplifiers. For example, two, three or four EPS 16's can extend each channel of an EPC 10 Double, triple or Quadro respectively to generate systems with 32, 48 and 64 channels. Systems based on two EPC 10 Quadro patch clamp amplifiers can increase this number to 128.

These multi-patch systems are controlled through PATCHMASTER software and can also be incorporated into your custom automated patch clamp system by virtue of the Batch Control Interface offered by the PATCHMASTER software.

The "selected" probe(s) of the PROBE SELECTOR behaves like a probe connected directly to the EPC 10, and is indicated by a LED on the front panel.

"Non-selected" probes are held at individual holding potentials in the medium gain range. Upon selection of a probe, the gain and holding potential specified of the corresponding amplifier are set.

Features:
  • Available version 1 x 16, 2 x 8, and 4 x4
  • A LED on the front panel of the EPS 16 PROBE SELECTOR indicates the currently "selected" probe.
  • "Non-selected" probes will be held at their last holding potential
  • Individual calibration parameters for all probes are stored
  • Pipette offset potentials and liquid junction potentials are taken into account when controlling the holding potential of selected and non-selected probes.
  • The probes connected to the EPS 16 PROBE SELECTOR can be automatically calibrated individually or all together in a complete calibration run.
  • High throughput acquisition support by PATCHMASTER