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Continuing the tradition of providing the world’s best electrophysiology amplifiers, the EPC 10
Double and Triple have all of the features of their predecessors, the EPC 9 Double and Triple;
but they go much further in offering many improvements that have been implemented according to the wishes,
suggestions and proposals of our customers.
The EPC 10 Double and EPC 10 Triple patch clamp amplifiers are the optimal instruments for performing
double or triple patch experiments. Although either two (EPC 10 Double) or three (EPC 10 Triple)
amplifiers are combined in a single housing; each amplifier is completely independent with clearly
defined operation and handling. HEKA’s software stimulates the desired amplifier and selected channels
are programmed without tedious connection of cables by the user.
The amplifiers and headstages are clearly identified, thus, the user can immediately assign the amplifiers
to particular patched cells. Although independent, the amplifiers can be stimulated simultaneously with
resulting simultaneous data acquisition. Current or voltage signals from multiple amplifiers can be
recorded, displayed and even analyzed online. This versatility makes these amplifiers ideal instruments
for experiments such as studying gap junction potentials, pre- and post-synaptic events, and even usage
in amperometric measurements.
Like the EPC 9 Double and EPC 9 Triple, the versatility of the EPC 10 Double and EPC 10 Triple stem
from their adjustment and control at the software level. Leak currents, capacitances, and series resistances
can instantly be neutralized automatically while you still retain the possibility of full manual control of the amplifier.
Voltage- and Current-Clamp experimental protocols are easily automated; not only ensuring simplicity,
great speed and accuracy but also providing enormous flexibility for the integration of extensions
such as photometric and fluorescence measurements.
The EPC 10 Double and EPC 10 Triple also provide economical solutions in comparison with the combination
of several individual instruments. They also have the advantages of optimized noise performance and
grounding over that of multiple external amplifiers.
In current clamp (CClamp) mode, the membrane potential (Vm) is measured and used to compute a current
waveform which is fed back into the cell. As a result, slow voltage drift and other artificial
voltage-dependent conductances are controlled and adjusted to a fixed value. This negates any readjustment
of the holding current while conducting CClamp experiments.
A new design of the pre-amplifier allows to perform "True CClamp" experiments. In CClamp mode, the headstage
acts as a voltage follower circuit, which guarantees very fast and accurate membrane potential recordings.
Similar to a classical microelectrode amplifier, the cell voltage is measured on a very high input resistance
and C-fast compensation is no longer necessary.
Using novel components and a new arrangement of the parts on a multi layer board, we drastically reduced
the dimensions of the headstage. The slim shape of the completely new designed headstage allows optimal access
to your cells. The connection to the pipette holder is achieved via a stable BNC connector.
Adapter plates for various micromanipulators are available from HEKA. 
Like the EPC 9, the versatility of the EPC 10 stems from it’s adjustment and control
at the software level. Leak currents, capacitances, and series resistance can instantly be neutralized automatically
while you still retain the possibility of full manual control of the amplifier. Voltage- and Current-Clamp experimental
protocols are easily automated; not only ensuring simplicity, great speed and accuracy but also providing enormous
flexibility for the integration of extensions such as photometric and fluorescence measurements.
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