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| Continuing the tradition of providing the world’s best electrophysiology amplifiers, the EPC 10 USB Quadro patch clamp amplifier is the optimal instrument for performing multi-patch experiments. Although four amplifiers are combined in a single housing; each amplifier is completely independent with clearly defined operation and handling. HEKA’s software stimulates the desired amplifier and selected channels are programmed without tedious connection of cables by the user. The amplifiers and headstages are clearly identified, thus, the user can immediately assign the amplifiers to particular patched cells. Although independent, the amplifiers can be stimulated simultaneously with resulting simultaneous data acquisition. Current or voltage signals from multiple amplifiers can be recorded, displayed and even analyzed online. This versatility makes these amplifiers ideal instruments for experiments such as studying gap junction potentials, pre- and post-synaptic events, and even usage in amperometric measurements. The versatility of the EPC 10 USB Quadro stems from its adjustment and control at the software level. Leak currents, capacitances, and series resistances can instantly be neutralized automatically while you still retain the possibility of full manual control of the amplifier. Voltage- and Current-Clamp experimental protocols are easily automated; not only ensuring simplicity, great speed and accuracy but also providing enormous flexibility for the integration of extensions such as photometric and fluorescence measurements. The EPC 10 USB Quadro also provides economical solutions in comparison with the combination of several individual instruments. It also has the advantage of optimized noise performance and grounding over that of multiple external amplifiers. In case more AD/DA channels are required to control peripheral devices, an additional LIH 8+8 interface can be connected and the software PATCHMASTER will control both devices in parallel. The additional channels appear in the drop-down channel selection lists of PATCHMASTER as if they were part of the EPC 10 USB Quadro |
The design of the pre-amplifier allows “True current clamp” experiments to be performed. In current clamp (CClamp) mode, the headstage acts as a voltage follower circuit, which guarantees very fast and accurate membrane potential recordings. The Low Frequency Voltage Clamp (LFVC) is a modified current clamp mode, that allows for measuring transient potentials, such as action potentials and synaptic potentials, as in the usual current clamp, while the average membrane potential is kept constant at a value chosen by the user. The slim shape of the completely new designed headstage allows optimal access to your cells. The connection to the pipette holder is achieved via a stable BNC connector. Adapter plates for various micromanipulators are available from HEKA. Features:
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