Features: Manual control by use of the knobsand switches on the front panel Digital control of the followingfunctions by the use of a computer: Gain, Mode of the EPC 8 (Voltage-clamp, Current-clamp etc.), Filter, 'Phase tracking' Parameters which are manually set on the front panel (except 'Phase tracking') can be read by the software. Holding potential range of +/-500 mV +/-200 mV pipette offset A low gain range allows currents up to 2 µA Built-in 'phase tracking' capabilities Variable hardware filters C-Slow compensation (0-1000 pF, calibrated) 100-130 V AC or 200-260 V AC switchable See requirements
					The letters EPC stand for Extracellular Patch Clamp, the method introduced by Neher and Sakmann (1976) for recording the currents in a small patch of membrane under voltage clam technical advances have occurred, most notably the discovery of the 'gigaseal' by E. Neher (1981), which have made the words extracellular and patch excessively restrictive in describing this instrument. Based on the excellent design of the EPC 7 improvements and extensions were made which make the EPC 8 a worthy successor of the EPC 7. In comparison to the EPC 7 the holding potential range is increased to +/- 500 mV and a new low gain range allows to measure currents up to 2 µA. A fast current-clamp mode is introduced, which allows better follow of rapid changes in membrane potential, such as in neuronal action potentials. The EPC 8 can be controlled manually like the EPC 7 by use of the knobs and switches on the front panel, but most of its functionality can also be controlled by use of a computer via appropriate hardware. The EPC 8 is adapted for use with ITC-16 and PULSE, but it can also be used with other data acquisition hardware and software.
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